“No donor”? Consider a haploidentical transplant
نویسندگان
چکیده
منابع مشابه
"No donor"? Consider a haploidentical transplant.
Haploidentical stem cell transplantation (HaploSCT) is an attractive option for patients requiring a hematopoietic stem cell transplant who do not have an HLA-matched donor, because it is cheaper, can be performed faster, and may extend transplantation to virtually all patients in need. Significant advances have been made in the recent decade with dramatic improvement in treatment outcomes. His...
متن کاملSelecting the best haploidentical donor.
The substantial evidence of the safety of human leukocyte antigen (HLA)-haploidentical (haplo) blood or marrow transplantation (BMT) has led to its increasing utilization. When prioritizing HLA-matched grafts, patients frequently have few or no donors from whom to choose. However, a given patient may have multiple suitable haplo donors. Therefore factors other than HLA-match become critical for...
متن کاملSelection of optimal alternative graft source: mismatched unrelated donor, umbilical cord blood, or haploidentical transplant.
Only 30% of patients who require an allogeneic hematopoietic cell transplant will have an HLA-matched sibling donor. A search for an unrelated donor will be undertaken for patients without a matched family donor. However, many patients, particularly patients of diverse racial and ethnic backgrounds, may not be able to rapidly identify a suitably matched unrelated donor. Three alternative graft ...
متن کاملAutoimmune hematological diseases following haploidentical donor hematopoietic stem cell transplant compared with matched sibling and unrelated donor
Autoimmune hematological diseases (AHDs) occur more frequently than other autoimmune complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and are often refractory to treatment. This study was to analyze the incidence and risk factors of AHDs as well as their response to treatment . Four hundred and forty-five adult malignant hematopoietic disorders underwent allo-H...
متن کاملThe Haploidentical Family Donor: A New Weapon against Hodgkin’s Lymphoma
The fraction of patients with Hodgkin’s Lymphoma (HL) who are not responsive to first-line or salvage therapy have a poor outcome and deserve investigation for the search of newer and effective drugs. Fortunately, those drugs are there and showed efficacy in late stages as well as in earlier phases of treatment [1-5]. Some are new, like Brentuximab Vedotin and Nivolumab, whereas others are not ...
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ژورنال
عنوان ژورنال: Blood Reviews
سال: 2015
ISSN: 0268-960X
DOI: 10.1016/j.blre.2014.09.009